The visitors made a perfect start as they hammered away at the line before Willo Bicknell burrowed over, Mike Cooke landing an excellent conversion.
Yet penalties from a scrum and off-side allowed Iwan Jenkins to trim the gap to a point.
And Albion then hit the front as their opponents spilt the ball in midfield, a kick ahead claimed by the hosts before Ben Moa dived under the posts.
Jenkins slotted a simple kick before landing with a harder one after full back Harry Legg crossed on the left.
Plymouth then pulled further clear as more Rams ill-discipline allowed them to kick to the corner.
And while the maul was repelled, Huw Taylor squeezed over for 25-7.
Rams reply before hosts pull clear
The Berkshire boys replied before the break, however, a spell of sustained pressure ending with Axel Kalling-Smith crossing on the left following a five-metre scrum.
Cooke was again on target before the half-time whistle was blown.
Any hopes of another rousing second-period fightback were extinguished in swift order, however.
Firstly, Joel Broadhurst slithered home from a couple of metres out, Rams then turning the ball over in midfield before a couple of missed tackles allowed Moa to double hist tally.
Jenkins slotted both conversions before things took another turn for the worse, Cooke sin-binned for a deliberate knock-on.
Baker breaks record, Tull touches down
James Baker came on for a semi/professional one-club era record-breaking 458th appearance, but his introduction failed to stem the tide as Moa completed his hat-trick at the back of a maul.
Rams responded as Aaron Tull grabbed his first try for the club with a short-range effort, but Plymouth passed their half-century as Jack Oulton replied in kind.
Conversions from Jenkins and Andrew Lamb left it 53-21, but it was the hosts who next scored their eighth and final try of the afternoon.
Rams had struggled under the high ball throughout the afternoon and on this occasion missed it completely, some slick off-loading then sending replacement Gabe Mead across the whitewash.
Jenkins took his personal tally to 20 with another kick, but the visitors salvaged something from their heaviest defeat in 10 years as Clow collected Lamb’s deft chip to dot down.
Rams remain sixth in the table ahead of a return to Old Bath Road next Saturday (3pm), relegated Leicester Lions the visitors.
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